My dog has hives after vaccines-allergic reaction
- Jennifer Misfeldt, MABTR
- Aug 19
- 1 min read

Allergic reactions to vaccines in dogs are uncommon but can happen. Most dogs tolerate vaccines well, but some may develop mild or more serious reactions. Here’s a breakdown:
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(Common) Reactions
These usually appear within a few hours and resolve on their own:
Lethargy (tiredness)
Mild fever
Soreness or swelling at the injection site
Reduced appetite
Temporary lumps under the skin (vet may recommend benedryl)
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Moderate Reactions
May need veterinary attention if persistent:
Vomiting
Diarrhea
Facial swelling (lips, eyelids, muzzle)
Hives or itchy bumps on the skin
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Severe (Rare, Emergency) Reactions – Anaphylaxis
These typically happen within minutes to an hour after vaccination and require immediate veterinary care:
Collapse or fainting
Difficulty breathing (wheezing, gasping)
Pale gums
Severe swelling of face/throat
Seizures
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Risk Factors
Small-breed dogs may be slightly more prone to reactions.
Reactions are more likely when multiple vaccines are given at once.
Dogs with a history of vaccine sensitivity.
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What to Do if Your Dog Has a Reaction
Mild: Monitor at home, contact your vet if symptoms worsen or don’t resolve in 24 hours.
Moderate: Call your vet promptly for advice—may need antihistamines or anti-inflammatory medication.
Severe: Treat as an emergency—go to the vet or emergency clinic immediately.
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Prevention & Management
Tell your vet if your dog has had a reaction before—pre-treatment with antihistamines or steroids may be recommended.
Spacing out vaccines instead of giving several at once can reduce risk.
Some dogs with severe past reactions may be exempt from certain vaccines, depending on laws and health risks.
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